Yami no Ketsuzoku: Kanketsu-hen is a direct sequel to Yami no Ketsuzoku. After a series of murders has occurred in Tokyo, Miyu Izawa, the heroine of the game and amateur detective endowed with supernatural senses, travels to Mexico with her friend Risa. There she has to learn about the history of the country's indigenous peoples, and venture into mysterious temples in order to finally discover the whole truth about recent horrifying events.