DuoZuplixo is a 2D platforming collect-a-thon with some RPG elements. You'll be taking control of two characters, Dr. Zuplow & Nora. You'll be able to switch between these two on the fly, and will need to make use of both of their abilities to collect all the Zuplonium Orbs and proceed through the areas. Alongside the Zuplonium Orbs you'll also find other secrets hidden throughout, such as Health & Attack Upgrades & tokens that allow you to access 3D bonus levels.​