Game cover: S.E.M.I.: Side Effects May Include...

S.E.M.I.: Side Effects May Include...

Release date: 23/01/2026 by Two Horn Unicorn

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Hack and slash/Beat 'em up • Indie • Arcade

Also known as: SEMI.exe

PC (Microsoft Windows)

Main story

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S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

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